Blar i SINTEF Open på forfatter "Sulheim, Snorre"
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Addressing uncertainty in genome-scale metabolic model reconstruction and analysis
Bernstein, David; Sulheim, Snorre; Almaas, Eivind; Segrè, Daniel (Peer reviewed; Journal article, 2021)The reconstruction and analysis of genome-scale metabolic models constitutes a powerful systems biology approach, with applications ranging from basic understanding of genotype-phenotype mapping to solving biomedical and ... -
Automatic reconstruction of metabolic pathways from identified biosynthetic gene clusters
Sulheim, Snorre; Fossheim, Fredrik A.; Wentzel, Alexander; Almaas, Eivind (Peer reviewed; Journal article, 2021)A wide range of bioactive compounds is produced by enzymes and enzymatic complexes encoded in biosynthetic gene clusters (BGCs). These BGCs can be identified and functionally annotated based on their DNA sequence. Candidates ... -
Dynamic Allocation of Carbon Storage and Nutrient-Dependent Exudation in a Revised Genome-Scale Model of Prochlorococcus
Ofaim, Shany; Sulheim, Snorre; Almaas, Eivind; Sher, Daniel; Segrè, Daniel (Peer reviewed; Journal article, 2021)Microbial life in the oceans impacts the entire marine ecosystem, global biogeochemistry and climate. The marine cyanobacterium Prochlorococcus, an abundant component of this ecosystem, releases a significant fraction of ... -
Enhancing Microbiome Research through Genome-Scale Metabolic Modeling
Ankrah, N.Y.D; Bernstein, David B.; Biggs, Matthew; Carey, Maureen; Engevik, Melinda; García-Jiménez, Beatriz; Lakshmanan, Meiyappan; Pacheco, Alan R.; Sulheim, Snorre; Medlock, Gregory L. (Peer reviewed; Journal article, 2021)Construction and analysis of genome-scale metabolic models (GEMs) is a well-established systems biology approach that can be used to predict metabolic and growth phenotypes. The ability of GEMs to produce mechanistic insight ... -
Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production
Sulheim, Snorre; Kumelj, Tjasa; van Dissel, Dino; Salehzadeh-Yazdi, Ali; Chao, Du; Van Wezel, Gilles P.; Nieselt, Kay; Almaas, Eivind; Wentzel, Alexander; Kerkhoven, Eduard J (Peer reviewed; Journal article, 2020)Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their genetic potential, including silent and metagenomic BGCs. Although the engineered Streptomyces coelicolor M1152 is a widely used host ... -
Predicting strain engineering strategies using iKS1317: a genome-scale metabolic model of Streptomyces coelicolor
Kumelj, Tjasa; Sulheim, Snorre; Wentzel, Alexander; Almaas, Eivind (Peer reviewed; Journal article, 2018)Streptomyces coelicolor is a model organism for the Actinobacteria, a phylum known to produce an extensive range of different bioactive compounds that include antibiotics currently used in the clinic. Biosynthetic gene ... -
A unified and simple medium for growing model methanogens
Ngoumelah, Daniel Dzofou; Harnisch, Falk; Sulheim, Snorre; Heggeset, Tonje Marita Bjerkan; Aune, Ingvild Haugnes; Wentzel, Alexander; Kretzschmar, Jörg (Peer reviewed; Journal article, 2023)Apart from their archetypic use in anaerobic digestion (AD) methanogenic archaea are targeted for a wide range of applications. Using different methanogenic archaea for one specific application requires the optimization ...